We develop practical synthetic chemistry that tackles challenging problems through organofluorine chemistry, methodology development and catalysis.

Our focus is new synthetic methods for organofluorine chemistry and the late-stage diversification of biologically relevant scaffolds. We design reactions for practical use: straightforward procedures,commercially available reagents and mild conditions. Working with industrial partners, we target chemistry with direct industrial relevance.

Our recent work includes:

Developing new deoxyfluorination methods and exploiting in situ acyl fluoride formation for coupling reactions.

Creating new fluorinated heterocyclic motifs.

Turning fluorine-containing waste streams into valuable chemical resources, including commodity refrigerant gases as low-cost building blocks for medicinal chemistry.

Developing new routes to metal-chelating molecules for anticancer treatments and organofluorine probes for this research.

Designing new protecting-group strategies using fluorinated groups that are straightforward to install and remove.