https://www.wdgbchem.com/hilights daily 0.75 2023-07-17 https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/15fd8abb-9739-40b4-86f7-df42704b46a3/Josh+Poster.jpg Highlights Josh giving his poster presentation on NCL at the MoSMed CDT annual conference https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/a3107380-a739-45a3-b47e-d0e1089fcfa1/Lewis+Symposium.jpg Highlights Lewis presenting his work on fluorinated peptoids at the Durham Postgraduate Symposium https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/47abe175-ab0e-44f7-b561-68cf0b1ceab7/Liam+Symposium.jpg Highlights Liam bestowing the virtues of pentafluoropyridine at the Durham Postgraduate Symposium https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/95c4d44f-0040-41be-b0a6-d3c4403c0c87/RAPS+2022.jpeg Highlights Will presents some of his recent work at Recent Appointees in Polymer Science (RAPS) 2022 - Northumbria University https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/5a64aa5f-40cb-4e9a-97a6-97f4e0878e8e/MosMed+Conference+2022.jpg Highlights Durham-Newcastle MoSMed CDT conference 2022 https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/a37a4033-3cba-475d-a040-eee36f51491b/Katherine.jpg Highlights Katherine receiving her 3 L conical flask https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/a9b824ba-341d-4226-9d1e-1311450f3b0a/tempImagez8RfKY.png Highlights Outtake from new group photoshoot https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/c0321ba5-8281-4bf4-a688-4f6435db14ed/Image.jpeg Highlights Brittain Group Christmas Outing 2022 https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/2d3a6a93-ba05-4ea8-9064-5cd1ed0aa56b/cc9bb48a-5f9e-4908-92f2-07ce5a33473d.JPG Highlights JSF Alumni from the John S. Fossey Memorial Symposium https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/1eac0df3-5dfe-4970-b8ed-cb5730a6bb21/John+Fossey+10.jpg Highlights Exchanging stories of our good friend John https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/d3b0996f-ec88-494e-bb95-a575166c557b/File+31-05-2024%2C+12+29+25.jpeg Highlights Will takes part in a lecture tour of Japan as part of CASE 2024. Picture outside Osaka University during cherry blossom season. https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/e6057dab-2125-4803-ae69-8608a97193a0/tempImagekQprFL.png Highlights Will takes a trip to Berlin to talk at the CRC Fluorine Specific Interactions Colloquium. https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/cf53b875-9e3a-4e87-808b-00a748a653f6/File+31-05-2024%2C+12+34+20.jpeg Highlights Katherine gives her 1st year MoSMed talk https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/3055f1a7-b1c2-49bc-8954-33b7645ce233/tempImageoN7hrH.png Highlights Group lunch to celebrate Will's promotion to Associate Prof. https://www.wdgbchem.com/contact daily 0.75 2022-08-25 https://www.wdgbchem.com/meet-the-group daily 0.75 2026-01-16 https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/1661873169078-JVWGDXYKMWERPCX9M6MK/57EC9E0B-A849-4194-B6ED-EEF263FAF299.jpeg Meet the Group https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/b6c578aa-a8b6-4cdb-a5a9-c0f40b8c1d90/Jia.jpg Meet the Group https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/9ca2dc78-c90c-4d91-9a43-9b41e7d95845/Chloe.jpeg Meet the Group https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/2619a261-5d9f-4828-a213-498879445dd0/IMG_6245.JPG Meet the Group https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/42331eba-bf99-4481-80f8-cd216f446ffa/Katherine.jpg Meet the Group https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/47f9a2b0-44c9-45f3-9ede-b746f2c2ceb1/cropped-9-93879_computer-icons-user-image-person-silhouette-user-silhouettes-5.png Meet the Group https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/47f9a2b0-44c9-45f3-9ede-b746f2c2ceb1/cropped-9-93879_computer-icons-user-image-person-silhouette-user-silhouettes-5.png Meet the Group https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/15a6c530-bf42-4e14-8e88-8cfc846b302e/will_brittain_003.jpg https://www.wdgbchem.com/home daily 1.0 2026-03-06 https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/4b8993ad-9da4-4aab-b146-38f87e44e3c2/AdobeStock_270026450.jpg https://www.wdgbchem.com/publications daily 0.75 2026-01-13 https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/843ef760-5fcf-4a77-986a-e75a9812d957/c5cc04886a.jpg Publications https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/1668700807391-4MHSJNNTHN3DDPBSD5VV/c5cy00182j.jpg Publications https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/932f5055-1d3c-4563-954c-c1124ff6c6e2/c6ob01623e.jpg Publications https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/bf1a1ddf-17a8-4ee9-aecf-287f674c6a10/c8ob02899k.jpg Publications https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/ae9191a5-6fc3-4e66-b7c1-0670a8b34d26/d2ob01268e.jpg Publications https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/264e2ea6-1604-477a-8939-02776aca3372/jceda8_v094i001.jpeg Publications https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/01ed5ab7-82d1-4bce-be21-178d289d564f/d3qo90053c.jpg Publications https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/bc0aeaa5-be84-423e-b95b-9dae35a15fb9/Untitled.jpg Publications - One-pot ester and thioester formation mediated by pentafluoropyridine (PFP) Acyl fluorides are valuable synthetic intermediates, but in some cases they can be challenging to handle and difficult to isolate given their susceptibility to degradation. In addition, many reagents utilised to prepare acyl fluorides are incompatible with in-situ generation strategies and require the acyl fluoride to be isolated before any further reaction can take place. The combination of these factors has meant that acyl fluorides are currently under investigated in nucleophilic substitution processes, and often only a limited substrate scope is tolerated where they have been used. Herein, we report that pentafluoropyridine can be utilised to generate acyl fluorides in situ under mild conditions, and that they can subsequently be used to generate a range of esters and thioesters. This methodology offers a simple one-pot synthesis of esters and thioesters directly from parent carboxylic acids. https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/d4110f67-427f-40a7-879f-ab1859c2e3bd/Triazole+TOC.jpg Publications - Enantiomer stability of atropisomeric 1,5-disubstituted 1,2,3-triazoles The synthesis and characterisation of axially chiral atropisomeric 1,5-disubstituted 1,2,3-triazoles is reported. Molecules designed to display restricted rotation about 1,2,3-triazole N-1-aryl or 1,2,3-triazole C-5-aryl bonds were investigated by physical and computational techniques. The barrier to 1,2,3-triazole N-1-aryl rotation was found to be higher than that for 1,2,3-triazole C-5-aryl rotation, confirming axial chirality stemming from restricted rotation about an N-1-aryl bond in a 1,5-disubstituted 1,2,3-triazole to be the most suitable for the development of an axial chirality triazole-based platform.. https://images.squarespace-cdn.com/content/v1/62f227d3441758609cc7bb14/03d911ac-32ae-4602-ab48-89658a234188/TOC.tif.png Publications - Carboxylic Acid Deoxyfluorination and One-Pot Amide Bond Formation Using Pentafluoropyridine (PFP) This work describes the application of pentafluoropyridine (PFP), a cheap commercially available reagent, in the deoxyfluorination of carboxylic acids to acyl fluorides. The acyl fluorides can be formed from a range of acids under mild conditions. We also demonstrate that PFP can be utilized in a one-pot amide bond formation via in situ generation of acyl fluorides. This one-pot deoxyfluorination amide bond-forming reaction gives ready access to amides in yields of ≤94%.